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article imageDoes an ancient bacterium hold the key to eternal life?

By Karen Graham     Oct 3, 2015 in Science
Injecting yourself with a bacterium that's 3.5 million years old is either the dumbest thing a person could do, or it's brilliant. But that is exactly what a Russian scientist has done, in a quest to see if Bacillus F has the answer to eternal life.
In 2009, at a site called Mammoth Mountain in Mamontovaya, Yakutia (Siberia), researchers stumbled across a previously unknown bacteria strain buried deep within the ancient permafrost.
Given the name, Bacillus F, scientists and researchers have studied the gram-positive, rod-shaped bacteria extensively. One researcher, Anatoli Brouchkov, the head of the Geocryology Department at Moscow State University, has been one of those scientists involved in studies of the strange bacteria.
Mammoth Mountain in Siberia s Sakha Republic.
Mammoth Mountain in Siberia's Sakha Republic.
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While there is very little literature on Bacillus F, we do know the bacterium, like many Bacillus species, is able to produce oval endospores by which the bacteria can reduce themselves and remain in a dormant state for very long periods of time when under environmental stress. This knowledge was mentioned in a story about Bacillus F in Pravda in March 2012.
Studies conducted on mice yield extraordinary results
Professor Sergey Petrov, chief researcher of Tyumen Scientific Centre, was in charge of the different experiments conducted on mice and fruit flies. One of the first things the research team noticed was the impact the bacteria had on their subject's longevity and fertility.
Initial experiments were conducted using mice and fruit flies.
Initial experiments were conducted using mice and fruit flies.
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“We made experiments with copepods, mice, crops and human blood cells. In all these experiments, Bacillus F stimulated the growth and also strengthened the immune system. The experiments on human erythrocytes and leucocytes were also very optimistic,” Petrov told the news media.
Remember that phrase, "The experiments on human erythrocytes and leucocytes were also very optimistic." The sentence is actually sort of vague. It doesn't mean the experiments were successful by any stretch of the imagination. But despite this, Anatoli Brouchkov decided to take matters into his own hands and use himself as a guinea pig.
As quoted in News.com.au, Brouchkov told the Siberian Times,“After successful experiments on [the] mice and fruit flies, I thought it would be interesting to try the inactivated bacterial culture [on myself]."
The newspaper story in the Siberian Times says that, in effect, the man is making himself into a walking, talking science experiment, to see if Bacillus F holds the key to eternal life.
Professor Anatoli Brouchkov.
Professor Anatoli Brouchkov.
YouTube
Brouchkov told Medical Daily, "I would say, there exist [in the world] immortal bacteria, immortal beings. They cannot die, to be more precise, they can protect themselves." He added, "Our cells are unable to protect themselves from damage, these bacteria cells are able to protect themselves.”
Brouchkov and his team have been able to sequence and decipher the Bacillus F DNA. Now they face the task of figuring out which genes are responsible for the longevity of the bacteria, as well as figuring out which proteins are responsible for protecting the DNA from damage, or as Brouchkov says, "What is providing this bacteria with vitality?"
As far as Brouchkov's health goes, he says he feels fine. In an interview on Russian television, he said, "I started to work longer, I've never had a flu for the last two years. But it still need the experiments. We have to work out how this bacteria prevents aging. I think that is the way this science should develop. What is keeping that mechanism alive?
This story is interesting and of some importance for a number of reasons. Brouchkov describes many of them in a paper he co-authored and presented at the Collected Proceedings of the 2nd International Conference. Cambridge, England, in 2002 entitled: COULD MICROORGA ISMS I N PERMAFROST HOLD THE SECRET OF IMMORTALITY? WHAT DOES THIS MEAN?
It is important to know why some bacteria have been able to survive for millions of years. What do they have that allows this to happen? And, perhaps more importantly, is the bacteria as old as the permafrost, or has contamination with more recent bacteria occurred? For those who are interested, read the paper, because it asks some fascinating questions.
More about eternal life bacterium, 3 million years old, bacillus f, Immune System, mammoth mountain
 
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