According to The Insight Partners new market research study titled “Transient Protein Expression Market Forecast to 2027 – COVID-19 Impact and Global Analysis – by product type, application, and end user,” the global transient protein expression market is expected to reach US$ 983.10 million by 2027 from US$ 660.00 million in 2019. The market is estimated to grow at a CAGR of 5.3% from 2020 to 2027.
Transient protein expression procedure has been widely in use for animal and plant cells for the last three decades. However, in the recent years, significant evolution in proteomics has resulted in the development of recombinant proteins. The effective results of transient protein expression in animals and plants have increased research and product development for human applications.
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Prominent players operating in transient protein expression market include THERMO FISHER SCIENTIFIC INC.; MERCK KGaA; QIAGEN; GenScript; Promega Corporation; Takara Bio Inc.; MERIDIAN BIOSCIENCE, INC.; New England Biolabs; Agilent Technologies, Inc.; Mirus Bio LLC; and Sino Biological Inc.
The market players are focused towards bringing new and innovative products and services to sustain their position in the market. For instance, in September, 2017, Thermo Fisher Scientific Inc. launched its new PureLink Fast Low-Endotoxin Plasmid Purification Midi and Maxi Kits which significantly reduces plasmid purification time to accelerate protein expression. The developments performed by the companies are helping the market to grow in the coming years.
The COVID-19 pandemic has resulted in rise in use of transient protein expression in vaccine development. Various researchers have started studying the novel coronavirus extensively, with the use of transient protein expression. For instance, in March–April 2020, Absolute Antibody (UK) increased the production of multigram quantities of multiple anti-SARS-CoV-2 spike proteins to develop neutralizing antibodies. Similarly, the transient protein expression was widely used to produce a positive control protein in the development of in-vitro diagnostics kits. Thus, increasing applications of protein expression are likely to favor the market growth.
Based on product type, the global transient protein expression market is segmented into instruments, reagents, vectors, and competent cells. In 2019, the instruments segment held the largest market share. This segment is also expected to dominate the market in 2027 as they are the reducing human input which enables continuous cell maintenance and protein production. Moreover, the same segment is anticipated to grow at the fastest rate during the forecast period.
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Various companies, including biopharmaceuticals and contract research and development organizations, have channelized their efforts toward the development of products based on transient protein expression. The adoption of transient protein expression allows companies to get various genes to develop recombinant proteins without delaying cell line generation. Thus, the quick process of cell line development with required gene expression, companies are widely attracted toward uniform proteins that have drug-like properties, which allows production of vaccines and viral vectors. In addition, the transient protein expression process is widely being used in the production of monoclonal antibodies, modified human proteins, growth factors and cytokines, hormones, and blood products.
The emergence of coronavirus pandemic is estimated to have a significant impact on the transient protein expression market. Majority of the pharmaceutical companies around the globe are engaged in the development of vaccine for coronavirus. However, this shift of focus for research and development is anticipated to have negative impact on the other segments of the market. Also, the disruptions in supply chain caused due to shut down of global operations are also projected to have adverse impact on the market by certain extent.
Many well-known as well as small local companies are present in the market to provide diversified products to its customers. The larger firms are adopting the strategy of acquiring small firms to enhance its product portfolio and expand its footprint in different geographies. Additionally various companies are also undergoing other strategic alliances such as collaborations and others to garner their significance and remain competitive in the market. Few on the important key developments from the industry are mentioned below:
In 2020 – Merck signed agreements licensing its CRISPR technology to two companies PanCELLa, a cell therapy firm, and Takara Bio USA, Inc., a biotechnology company. Licenses aim to accelerate drug discovery research leading to the development of new therapies, PanCELLa agreement marks Merck’s first CRISPR license for bioproduction, Takara Bio USA agreement gives access to Merck’s CRISPR integration and vector technologies for Takara’s vector products and cell engineering services.
In 2018 – QIAGEN announced the appointment of The Scientific Group, a South Africa-based company and a wholly-owned subsidiary of Ascendis Medical, as its exclusive commercial partner for Africa, excluding South Africa and the Maghreb. The agreement will raise the profile of QIAGEN’s Sample to Insight solutions in Africa and benefit a region with growing needs for modern molecular testing technologies in healthcare and the life sciences.
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