DelveInsight’s, “Small Cell Lung Cancer Pipeline Insight, 2022,” report provides comprehensive insights about 100+ companies and 100+ pipeline drugs in Small Cell Lung Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
The Small Cell Lung Cancer pipeline is very robust, and the market is expected to grow in the coming years as new players will enter into the market and provide good competition to the competitors.
Key takeaways from the Small Cell Lung Cancer Pipeline
- DelveInsight’s Small-cell Lung Cancer Pipeline analysis depicts a robust space with 100+ active players working to develop 100+ Small-cell Lung Cancer treatment pipeline therapies.
- Some of the key Small-cell Lung Cancer companies proactively working to develop potential drug candidates to improve the Small-cell Lung Cancer treatment scenario include Ascentage Pharma, Merck & Co, AstraZeneca, Advenchen Laboratories, Advanced Accelerator Applications, Trillium Therapeutics, Wigen Biomedicine, Linton Pharm, Carrick Therapeutics, Xencor, Aileron Therapeutics, Ipsen, Celgene, Lee’s Pharmaceutical Limited, AbbVie, Chipscreen Biosciences, Shanghai Henlius Biotech, CSPC ZhongQi Pharmaceutical Technology, Impact Therapeutics, Amgen, Bristol-Myers Squibb, Genentech, Sorrento Therapeutics, DAIICHI SANKYO COMPANY, BioNTech, Harpoon Therapeutics, Genprex, Inc., Tarveda Therapeutics, Taizhou HoudeAoke Biomedical Co., Ltd., BeiGene, HaiHe Biopharma, Kartos Therapeutics, Inc., Boehringer Ingelheim, Y-mAbs Therapeutics, CStone Pharmaceuticals, EpicentRx, Inc., Pfizer, Mologen, Cybrexa Therapeutics, and many others.
- Essential Small-cell Lung Cancer pipeline therapies such as APG-1252, SYHA 1807, BNT 411, BMS 986012, LY 2510924, Serplulimab, Tiragolumab, Socazolimab, DS-7300, ABBV-011, HPN328, REQORSA, PEN-221, Gimatecan, LP002, LY01610, PLM60, Ociperlimab, KRT-232, BI 764532, Nivatrotamab, CS1001, RRx-001, PF-06821497, CC-90011, AL3810, Lefitolimod, ALRN-6924, CBX-12, and others are under development in different phases of clinical trials.
- The Small-cell Lung Cancer Companies and academics are working to assess challenges and seek opportunities that could influence Small Cell Lung Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Small Cell Lung Cancer.
Recent Developmental Activities in the Small Cell Lung Cancer Pipeline
- In March 2022, Luye Pharma Groupannounced that it has filed a New Drug Application (NDA) in Hong Kong, China for Lurbinectedin, for the treatment of adult patients with metastatic Small-cell Lung Cancer (SCLC) with disease progression on or after receiving platinum-based chemotherapy. Lurbinectedin is an innovative oncology drug licensed to Luye Pharma by PharmaMar.
- In March 2022, Harpoon Therapeutics, Inc.announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation for HPN328, a delta-like ligand 3- (DLL3) targeting TriTAC®, for the treatment of Small-cell Lung Cancer (SCLC). A Phase 1/2 clinical trial is currently ongoing for HPN328 in the SCLC patient population.
- In March 2022, Akeso, Inc.announced that it has entered into a collaboration agreement with Shenzhen Chipscreen Biosciences, Ltd. (SHA Code 688321) to conduct a Phase Ib/II clinical study of combination therapy of Cadonilimab (PD-1/CTLA-4 bispecific antibody, AK104) and Chiauranib (a highly selective Aurora B/VEGFR/PDGFR /c-Kit/CSF1R inhibitor) in patients with ES-SCLC which progressed on combination therapy of platinum-based chemotherapy and PD-(L)1 inhibitor as first-line treatment.
- In March 2022, Shanghai Henlius Biotech, Inc., announced that the investigational new drug application (IND)of an international multicenter phase 3 studies of HANSIZHUANG (serplulimab), an innovative anti-PD-1 monoclonal antibody (mAb) independently developed by the Company, in combination with chemotherapy and concurrent radiotherapy in patients with limited-stage Small-Cell Lung Cancer (LS-SCLC) has been approved by the National Medical Products Administration (NMPA). Previously, the global multi-center phase 3 study of HANSIZHUANG for the first-line treatment of extensive-stage small-cell lung cancer (ES-SCLC) has met the primary study endpoint of the overall survival (OS), and its NDA in China and MAA in the EU are expected to be filed in 2022, making HANSIZHUANG potentially the world’s first PD-1 inhibitor for the first-line treatment of SCLC.
- In January 2022, Genprex, Inc.announced that it has expanded its oncology research and development pipeline to include Small-cell Lung Cancer (SCLC) as an additional disease indication for its lead drug candidate, REQORSA
Immunogene Therapy. - In December 2021, Shanghai Henlius Biotech, Inc.announced that the first interim analysis met the primary study endpoint of the overall survival (OS) of Phase 3 clinical study (NCT04063163) of its innovative PD-1 inhibitor serplulimab in combination with chemotherapy in previously untreated patients with extensive-stage small-cell lung cancer (ES-SCLC). There is no anti-PD-1 mAb approved for the treatment of extensive-stage small-cell lung cancer (ES-SCLC) worldwide.
Request a sample and discover more about the report offerings @ Small-cell Lung Cancer Pipeline Outlook Report
Small-cell Lung Cancer Overview
Small-cell Lung Cancer is characterized as a neuroendocrine carcinoma because the cancer cells have features of nerve cells and endocrine (hormone-secreting) cells. Endocrine tissue is a specialized tissue that contains hormone-secreting cells. These hormones have a variety of functions within the body. Common Small-cell Lung Cancer symptoms include a cough that doesn’t get better, chest pain that is worse when coughing, laughing or taking a deep breath, shortness of breath, coughing up blood (hemoptysis), and hoarseness or wheezing. Some affected individuals can develop loss of appetite, unintended weight loss, fatigue, and recurrent episodes of lung infections such as pneumonia or bronchitis. A Small-cell Lung Cancer diagnosis is based upon the identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests.
Small-cell Lung Cancer Pipeline Insight Report
In the Small-cell Lung Cancer pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Small Cell Lung Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Small-cell Lung Cancer Emerging Drugs Profile
AMG 757: Amgen
AMG 757 is a half-life extended (HLE) anti- delta-like ligand 3 (DLL3) x anti-CD3 BiTE (bispecific T cell engager) molecule. It is being investigated in Phase I clinical studies for the treatment of prostate cancer and Small cell lung cancer.
APG-1252: Ascentage Pharma
APG-1252 is a highly potent, small-molecule based Bcl-2 family protein inhibitor drug. APG-1252 is designed to treat SCLC, NSCLC, lymphoma, and other solid tumors by selectively blocking Bcl-2 and Bcl-xL to restore the apoptosis process. The drug is in Phase I/II clinical studies for the treatment of SCLC.
Small-cell Lung Cancer Therapeutics Assessment
The Small-cell Lung Cancer Pipeline report proffers an integral view of the Small-cell Lung Cancer emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action and Route of Administration.
Small-cell Lung Cancer Pipeline Profile
There are approx. 100+ key companies which are developing the therapies for Small Cell Lung Cancer. The companies which have their Small Cell Lung Cancer drug candidates in the most advanced stage, i.e. Phase III include, Ipsen.
Learn more about the novel and emerging Small-cell Lung Cancer pipeline therapies @ Small-cell Lung Cancer Ongoing Clinical Trials Analysis
Scope of the Small Cell Lung Cancer Pipeline
- Coverage: Global
- Therapeutic Assessment By Small-cell Lung Cancer Product Type: Mono, Combination, Mono/Combination
- Therapeutic Assessment By Small-cell Lung Cancer Clinical Trial Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III, Pre-registration, Inactive candidates
- Therapeutics AssessmentBy Small-cell Lung Cancer Therapeutics Route of Administration: Oral, Intravenous, Inhalation, Subcutaneous
- Therapeutics AssessmentBy Small-cell Lung Cancer Therapies Molecule Type: Gene therapy, Stem cell therapy, Small molecules
- Therapeutics AssessmentBy Small-cell Lung Cancer Therapies Mechanism of Action: CXCR4 receptor antagonists, Antibody-dependent cell cytotoxicity, Fucosyl GM1 ganglioside inhibitors, Toll-like receptor 7 agonists, Proto-oncogene protein c-bcl-2 inhibitors, Lysine specific demethylase 1 inhibitors
- Key Small-cell Lung Cancer Companies: Ascentage Pharma, Merck & Co, AstraZeneca, Advenchen Laboratories, Advanced Accelerator Applications, Trillium Therapeutics, Wigen Biomedicine, Linton Pharm, Carrick Therapeutics, Xencor, Aileron Therapeutics, Ipsen, Celgene, Lee’s Pharmaceutical Limited, AbbVie, Chipscreen Biosciences, Shanghai Henlius Biotech, CSPC ZhongQi Pharmaceutical Technology, Impact Therapeutics, Amgen, Bristol-Myers Squibb, Genentech, Sorrento Therapeutics, DAIICHI SANKYO COMPANY, BioNTech, Harpoon Therapeutics, Genprex, Inc., Tarveda Therapeutics, Taizhou HoudeAoke Biomedical Co., Ltd., BeiGene, HaiHe Biopharma, Kartos Therapeutics, Inc., Boehringer Ingelheim, Y-mAbs Therapeutics, CStone Pharmaceuticals, EpicentRx, Inc., Pfizer, and many others.
- Key Small-cell Lung Cancer Pipeline Therapies: APG-1252, SYHA 1807, BNT 411, BMS 986012, LY 2510924, Serplulimab, Tiragolumab, Socazolimab, DS-7300, ABBV-011, HPN328, REQORSA, PEN-221, Gimatecan, LP002, LY01610, PLM60, Ociperlimab, KRT-232, BI 764532, Nivatrotamab, CS1001, RRx-001, PF-06821497, CC-90011, AL3810, and others
Table of Content
- Introduction
- Small Cell Lung Cancer Executive Summary
- Small Cell Lung Cancer: Overview
- Small Cell Lung Cancer Pipeline Therapeutics
- Small Cell Lung Cancer Therapeutic Assessment
- Small Cell Lung Cancer – DelveInsight’s Analytical Perspective
- In-depth Commercial Assessment
- Small Cell Lung Cancer Collaboration Deals
- Late Stage Products (Phase III)
- Pembrolizumab: Merck & Co
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Dostarlimab: GlaxoSmithKline
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- AMG 757: Amgen
- Drug profiles in the detailed report…..
- Preclinical/Discovery Stage Products
- S 055746: Vernalis
- Drug profiles in the detailed report…..
- Inactive Products
- Small Cell Lung Cancer Key Companies
- Small Cell Lung Cancer Key Products
- Small Cell Lung Cancer- Unmet Needs
- Small Cell Lung Cancer- Market Drivers and Barriers
- Small Cell Lung Cancer- Future Perspectives and Conclusion
- Small Cell Lung Cancer Analyst Views
- Small Cell Lung Cancer Key Companies
- Appendix
Key Questions
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Small Cell Lung Cancer drugs?
- How many Small Cell Lung Cancer drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Small Cell Lung Cancer?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Small Cell Lung Cancer therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Small Cell Lung Cancer and their status?
- What are the key designations that have been granted to the emerging drugs?
For further information on the Small-cell Lung Cancer current pipeline therapeutics, reach out to Small-cell Lung Cancer Treatment Landscape
About Us
