Global Oligonucleotide Synthesis Market Size Hit USD 26.58 Billion at a CAGR of 16.8% in 2030

The global oligonucleotide synthesis market size is expected to reach USD 26.58 Billion in 2030 and register a revenue CAGR of 16.8% over the forecast period, according to the latest report by Reports and Data. Increasing use of synthesized oligonucleotides in molecular diagnostics and therapeutic applications, as well as raised demand for high-end bespoke oligos and purification, are a few of the key factors driving revenue growth of the oligonucleotide synthesis market. A growing number of FDA-approved oligonucleotide drugs, an increased emphasis on customized or personalized medicine, and a continued focus on the development of therapeutics for rare diseases are further contributing to revenue growth of the market. Oligonucleotides have a high application potential for use in the treatment of a wide range of medical conditions.

Oligonucleotides are produced with great precision, making them highly targetable with minimal side effects. Oligonucleotides can be modified to hybridize with particular pathogenic DNA or RNA, and they are utilized in TB, malaria, and HIV screening tests. Rising demand for genetic tests, mostly due to an increase in the frequency of hereditary disorders like cancer, as well as acceptability, necessitate substantial oligo production capacity and short turnaround times. The World Health Organization (WHO) reports that Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death worldwide, accounting for 3.23 million fatalities in 2019. In medicine and life science research, oligonucleotide synthesis, also known as gene synthesis, is used for a number of purposes, such as the production of primers for Polymerase Chain Reaction (PCR) sequencing and amplification, hybridization probes for complementary DNA or RNA detection, synthetic genes, anti-sense oligonucleotides [several Small Interfering RNAs (siRNAs) currently undergoing clinical trials], and tools for the targeted introduction of genetic mutations.

Oligonucleotide-based therapeutics are intermediate in size, have considerably greater target selectivity, and have fewer off-target effects than small compounds. Antisense RNAs, microRNAs (MIR), small interfering RNAs (siRNA), and aptamers are examples of Oligonucleotide Therapeutics (OTs) that are now being researched for their possible applicability in neurological ailments, cancer, and even orphan diseases. However, concerns about the difficulties associated with therapeutic oligos and challenges connected to the delivery of oligonucleotide therapeutics to particular targets are expected to provide some restraints to revenue growth of the market.

Some major companies in the global market report include Danaher, Thermo Fisher Scientific, Merck KGaA, Eurofins Scientific, KANEKA CORPORATION, Agilent Technologies, Biolytic Lab Performance Inc., Generi Biotech, Biogen and Ionis Pharmaceuticals, Inc.

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Market Overview:

The research report assesses the market dynamics, market landscape, company profiles, production and manufacturing capacity, year-on-year growth rate, SWOT analysis, and Porter’s Five Forces analysis. The report estimates the market size, market growth, and provides an accurate forecast for the key segments of the market for the forecast period of 2022-2030. The report also covers an in-depth analysis of the key competitors of the market, along with their growth strategies and business expansion plans.

The Oligonucleotide Synthesis Market has been segmented into key regions of the world and offers an analysis of growth rate, market share, market size, current and emerging trends, production and consumption ratio, industrial chain analysis, demand and supply, import and export, revenue contribution, and presence of key players in each region. A country-wise analysis of the market is offered in the report to gain a better understanding of the regional spread and progress of the Oligonucleotide Synthesis Market.

Further key findings from the report suggest,

• The synthesized oligonucleotides segment is expected to register a significant revenue growth rate during the forecast period. One of the most prevalent applications for oligonucleotides is PCR primers. Primers are intended to have at least part of their sequence complementary to the 5′ end of the sequence being amplified. Synthetic oligonucleotides are mostly used as relatively short probes and primers (up to 30-mer) in a wide range of applications.
• The therapeutic segment is expected to register a significant revenue growth rate over the forecast period owing to the potential of oligonucleotide drugs for treating or managing a wide range of disorders. Oligonucleotide medications are used to treat neurological illnesses including amyotrophic lateral sclerosis, Huntington’s disease, and spinal muscular atrophy, as well as respiratory problems like asthma and COPD, diabetic retinopathy, and several cancers. Specific structural variations of oligonucleotide treatment, such as changes in the nucleotide backbone or sugar moieties, aid in the incorporation of desired qualities into the medication molecule, boosting its safety and efficacy, which drives the segment’s growth.
• The pharmaceutical & biotechnology companies segment is expected to register a rapid revenue growth rate in 2021. High-value investments in various research & development projects for OTs by major biotechnology and pharmaceutical companies are one of the key factors driving revenue growth of the market. Rising number of companies are focused on curing rare diseases, with 14 oligonucleotide therapies now authorized by the FDA and European Medicines Agency (EMA).
• North America accounted for the largest revenue share in the global oligonucleotide synthesis market in 2021, owing to a rising number of innovations and various major pharmaceutical & biotechnology companies increasingly involved in developing processes that would be more scalable and sustainable. Growing number of clinical trials and preclinical trials for oligo-based products are further attributing to revenue growth of the market in this region. On 28 January 2022, Maravai LifeSciences, Inc., a global provider of life science reagents and services to researchers and biotech startups, announced today that it has acquired MyChem, LLC for USD 240 million in cash at closing with the possibility of additional contingent cash consideration based on achievement of certain conditions after closing. With the medicines and vaccine application industries growing quickly, the purchase will increase Maravai’s product line of key contributions.
• Some major companies in the global market report include Danaher, Thermo Fisher Scientific, Merck KGaA, Eurofins Scientific, KANEKA CORPORATION, Agilent Technologies, Biolytic Lab Performance Inc., Generi Biotech, Biogen and Ionis Pharmaceuticals, Inc.
• On 19 October 2022, Telesis Bio which is a leader in automated multi-omic and synthetic biology solutions, and Cellibre which is a leading manufacturing technology company, are collaborating to optimize the development and validation of Telesis Bio’s BioXp Digital-to-Biological Converter (DBC) instrument for fully automated manufacturing of on-demand CRISPR-Cas9 guide RNA (gRNA) for genome editing.

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For the purpose of this report, Reports and Data has segmented the global oligonucleotide synthesis market based on product, application, end-user, and region:

Product Outlook (Revenue, USD Billion; 2019-2030)

• Synthesized oligonucleotides
• Oligonucleotide-based drugs
• Equipment
• Reagents

Application (Revenue, USD Billion; 2019-2030)

• Research
• Therapeutic
• Diagnostic

End-User Outlook (Revenue, USD Billion; 2019-2030)

• Pharmaceutical & biotechnology companies
• Hospitals
• Diagnostic laboratories
• Academic research institutes
• Contract Research Organizations (CROs) & Chief Medical Officers (CMOs) treatment

Regional Outlook (Revenue, USD Billion; 2019-2030)

• North America
  • U.S.
  • Canada
  • Mexico
• Europe
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Sweden
  • BENELUX
  • Rest of Europe
• Asia-Pacific
  • China
  • India
  • Japan
  • South Korea
  • Rest of APAC
• Latin America
  • Brazil
  • Rest of LATAM
• Middle East & Africa
  • Saudi Arabia
  • UAE
  • South Africa
  • Israel
  • Rest of MEA

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 Key Advantages of Oligonucleotide Synthesis Market Report:

• Identification and analysis of the market size and competition
• Qualitative and quantitative analysis of the market data
• Data validated by industry experts after extensive primary and secondary research
• Extensive regional analysis of the Oligonucleotide Synthesis industry
• Profiling of key players along with their business overview, business strategies, deals and partnerships, and product portfolio
• SWOT and Porter’s Five Forces Analysis for in-depth understanding of the competitive landscape
• Feasibility analysis and investment analysis to enable strategic investment decisions
• Analysis of opportunities, drivers, restraints, challenges, risks, and limitations

Conclusively, all aspects of the Oligonucleotide Synthesis Market are quantitatively as well qualitatively assessed to study the global as well as regional market comparatively. This market study presents critical information and factual data about the market providing an overall statistical study of this market on the basis of market drivers, limitations and its future prospects.

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