New York, USA – December 17, 2021 – Creative Biogene, the top leading biotechnology products and services provider, is dedicated to providing customized molecular biology reagents and professional technical services to customers in the life science research field. With years of experience, Creative Biogene is skilled in covering the full scope of biotechnology needs of early drug discovery and drug development. Currently, Creative Biogene releases reliable and high-quality pseudovirus services for supporting the studies of SARS-CoV-2.
The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is threatening the health of people all over the world. Due to its strong transmission capacity, the virus has reached many parts of the world. As the virus continues to spread globally, understanding the mechanism of SARS-CoV-2 is essential for drug discovery and vaccine development. Creative Biogene’s COVID-19 pseudovirus service can study the SARS-CoV-2 virus in cell culture. This service is very suitable for screening neutralizing antibodies in patient sera, verifying inhibitors of Spike-ACE2 interaction, and developing COVID-19 vaccines.
Creative Biogene uses a lentivirus packaging system to package the SARS-CoV-2 (2019-nCoV, COVID-19 virus) S protein into a surface capsid glycoprotein, and contains a GFP and luciferase dual reporter gene as a pseudovirus model. The virus can infect cell lines that overexpress the ACE2 gene. Researchers can observe GFP through a microscope and detect the value of luciferase to determine the infection efficiency.
The SARS-CoV-2 (2019-nCoV, COVID-19 virus) nucleic acid detection experiment mainly includes: virus sample collection, viral nucleic acid extraction, RNA reverse cDNA, QPCR system preparation, and airborne detection. A problem in any of these links will cause the test to fail, and the diagnosis cannot be confirmed. In the meantime, Creative Biogene developed a set of nucleic acid detection pseudovirus vectors based on the retrovirus/lentivirus system based on its own technological advantages, which mimics RNA viruses to the greatest extent and has high biological safety and stability. It can be used for the whole process of nucleic acid detection quality control and simulation test in the development stage of the kit.
Creative Biogene can provide a comprehensive product line for SARS-CoV-2 (2019-nCoV, COVID-19 virus) research, including but not limited to:
SARS-CoV-2 S Pseudotyped GFP Lentivirus (Alpha strain S)
SARS-CoV-2 S Pseudotyped GFP Lentivirus (Beta strain S)
SARS-CoV-2 S Pseudotyped GFP Lentivirus (Delta strain S)
SARS-CoV-2 S Pseudotyped GFP Lentivirus (Omicron strain S)
SARS-CoV-2 S Pseudotyped Luciferase Lentivirus
SARS-CoV-2 S Pseudotyped Luciferase Lentivirus (Alpha strain S)
SARS-CoV-2 S Pseudotyped Luciferase Lentivirus (Beta strain S)
“Creative Biogene works with researchers and scientists around the world to provide high-quality pseudovirus services to support SARS-CoV-2 research.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “In order to better support SARS-CoV-2 research, Creative Biogene provides more related virus particles. For any specific needs related to virus, Creative Biogene is also capable to provide customized solutions.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.