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Novel approach for tumor detection

By Tim Sandle     Feb 3, 2014 in Science
Scientists have pioneered a new gene sequencing method to test for abnormal DNA in cancerous tumor cells. This method paves the way for routine genetic testing in personalizing cancer care.
The genomic sequencing test is called the Ion Torrent AmpliSeq Cancer Hotspot Panel. The method has been adopted to examine patient tumor tissue. For the evaluation, physicians and scientists tested tumor samples from metastatic colon cancer, melanoma, gliomas (a type of tumor that starts in the brain or spine), and non-small cell lung cancers.
The basis of the test is that DNA is supposed to be well ordered, and it is considered damaged or mutated when there is an extra or missing section. Genetic mutations can be inherited or caused by environmental factors such as exposure to sunlight, cigarette smoke, or other carcinogens. Damaged DNA can send out the wrong messages to cells: telling them to multiply and grow in ways that can lead to tumors. By identifying the specific mutations, using the novel technology, in a tumor, physicians can chose medications that precisely target that location for treatment.
The development was undertaken at the Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC). The findings have been published in the journal Clinical Chemistry and Laboratory Medicine, in a paper titled “Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutations.”
More about Tumor, Cancer, Genetics, Dna
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