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article imageLab creates first human stomach tissue in a dish

By Tim Sandle     Nov 3, 2014 in Science
Cincinnati - Researchers have created three-dimensional human stomach tissue in a laboratory by using stem cells. The living tissue can be used to develop treatments against diseases like cancer.
For the study, biologists used pluripotent stem cells to create the functional stomach tissue. Human pluripotent stem cells are special cells that have the ability to become any cell type in the body. Within four weeks, the scientists were able to create three dimensional human gastric tissue of about 3mm (1/10th of an inch) in diameter.
With the research, the scientists in effect grew a miniature version of the stomach. The use of such human tissue is regarded to be more useful to scientists than using rodents to carry out research (currently mice are the primary animals used to study the stomach.)
The stomach tissue could prove to be very useful for tool for examining the pattern of diseases of the stomach. This includes cancer and diabetes (obesity triggered diabetes is a major health concern.) Already the mini-stomachs (termed gastric organoids) have been used to examine infections caused by Helicobacter pylori bacteria. This bacterium is a major cause of peptic ulcer disease and stomach cancer.
More details about the research are outlined in the video below:
The research should also help to inform about how the human stomach develops; this area of development remains unclear. This aspect could help further medical understanding with childhood diseases.
The research was undertaken at the Cincinnati Children's Hospital Medical Center. The findings have been published in the journal Nature, in a study called “Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.”
More about Stomach, Stem cells, petri dish
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