http://www.digitaljournal.com/article/358736

Cryogenic success using rats

Posted Sep 20, 2013 by Tim Sandle
Researchers have successfully injected a compound into rats in a cold room. The bodies slowed down; however, when the rats were revived, they were healthy.
File photo: A laboratory rat is a rat of the species Rattus norvegicus (brown rat) which is bred and...
File photo: A laboratory rat is a rat of the species Rattus norvegicus (brown rat) which is bred and kept for scientific research
CRIIGEN
The study was conducted to mimic the cryogenic suspension effects in animals, with a possible view to see if people can be cryogenically frozen and then revived (such as situation might be useful for deep space exploration). The research on the rats was parts of an attempt to induce the metabolically lethargic state known as torpor in the animals. The rats were not in a coma, nor were they asleep or truly hibernating, but in a ‘suspended state’.
The study showed that as the heart rates slowed their brain activity became sluggish and body temperature plummeted. This took place as the rats’ core temperature dropped from about 38° to about 28° C, or 82° Fahrenheit. After being frozen, the rats were gradually revived and the test subjects survived.
Cryogenic suspension is a tricky process and the survival rates are low. This study with the rats was regarded as a success, although more research is required and the use of people in trials remains a long way off.
The research was led by Domenico Tupone of Oregon Health & Science University in Portland, U.S. The findings have been published in the Journal of Neuroscience. The paper is titled “Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.”