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Development of Two Tests for Rapid Diagnosis of Resistance to Antibiotics

By Tim Sandle
Posted Dec 19, 2012 in Science
Two new tests capable of rapidly diagnosing resistance to wide-spectrum antibiotics have just been developed by Inserm Unit 914 "Emerging resistances to antibiotics" (Bicêtre Hospital, Le Kremlin-Bicêtre) under the direction of Professor Patrice Nordmann.
The tests means that certain bacteria that are resistant to the most used and the most important antibiotics in hospitals can be identified within two hours. The main targeted bacteria are enterobacteriacae (such as E. coli), that are responsible for infections.
These tests (Corba NP test and ESBL NDP test) are based on the acidification properties generated by the activity of the enzymes (ß-lactamases and carbapenemases) when they are in the presence of an antibiotic. If any one of these enzymes is present, the medium becomes acid and the acidity indicator (pH) turns from red to yellow.
These works were published in Emerging Infectious diseases and The Journal of Clinical Microbiology.
For further details, see the INSERM (Institut national de la santé et de la recherche médicale).

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