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article imageBio patch can re-grow bone

By Tim Sandle     Nov 16, 2013 in Science
A bio patch has been created that can regenerate missing or damaged bone by putting DNA into a nano-sized particle able to deliver bone-producing instructions directly into cells.
The newly developed bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, the gene-encoding bio patch successfully regrew bone fully enough to cover skull wounds in test animals. It also stimulated new growth in human bone marrow stromal cells in lab experiments.
Essentially, what the research team have been able to do is transplant DNA to cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration.
Corresponding author Aliasger Salem, professor at Iowa's College of Pharmacy, told Medical News about the benefit of directly delivering the DNA to cells: “If you deliver just the protein, you have keep delivering it with continuous injections to maintain the dose. With our method, you get local, sustained expression over a prolonged period of time without having to give continued doses of protein.”
The researchers think that the patch has several potential uses in dentistry. The next step of the research will involve human trials.
The research was carried out at the University of Iowa. The findings have been published in the journal Biomaterials; the paper is titled “The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor”.
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