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Is an Alzheimer’s disease treatment imminent? Special

By Tim Sandle     Nov 9, 2013 in Health
A novel compound called IRL-1620 may be useful in treating Alzheimer’s disease as it has been shown to prevent cognitive impairment in animal models.
For the research, scientists at the Midwestern University administered Amyloid beta (Aβ), a main component of certain deposits located in Alzheimer’s disease patients’ brains, into both normal and diabetic rats on different days over a two-week period. To find out more, Digital Journal spoke with Anil Gulati, M.D., Ph.D., FCP, who led the project.
Dr. Gulati explained that: “spatial learning and memory of the rats were tested in a Morris water maze. The pool was divided into four equal quadrants, and an escape platform was hidden below the surface at a fixed location in one of the quadrants.”
Dr. Gulati added that “the rats had to find the platform within 60 seconds. The average time it took on day four of the study, for Aβ-treated rats to locate the platform was 55.05 seconds, though a majority of this group was not able to find it in the designated time. Aβ rats treated with IRL-1620 were able to locate the platform in 26.53 seconds, nearly half the time. After five days, Aβ rats treated with IRL-1620 showed a 60 percent improvement in learning and memory.”
Further research will be carried out to see if the results can be replicated. The long-term aim is to develop a treatment for the disease. A breakthrough Alzheimer's treatment would target the underlying disease and stop or delay the cell damage that eventually leads to the worsening of symptoms.
Alzheimer’s disease is a form of dementia that worsens over time, leading to a slow decline in cognitive functions and affecting memory, thinking, and behavior. More than 5 million Americans are living with the condition, according to the Alzheimer’s Association.
The new research is due to be presented at the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in San Antonio, November 10–14.
More about Alzheimers Disease, Alzheimer's disease, cognitive, Brain
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