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article imageLink between 'good cholesterol' and breast cancer

By Tim Sandle     Oct 13, 2013 in Health
Philadelphia - While high levels of high density lipoprotein (HDL) — "good cholesterol" — offers some protection against heart disease, there could be a link between this type of cholesterol and breast cancer.
Recent research suggests that high density lipoprotein (HDL) or "good cholesterol" may be responsible for certain types of breast cancer. HDL is one of the five major groups of lipoproteins
To study the effect of HDL on cancer cells at the molecular level, scientists exposed breast cancer cell lines to HDL and noticed that signaling pathways involved in cancer progression were activated, and that the cells began to migrate in an experimental model mimicking metastasis. When the researchers limited the expression of the HDL receptor, they found that the effects decreased.
Thus the study supported the idea that HDL plays a role in the development of aggressive breast cancers and that inhibiting its function in breast cancer cells may stall cancer growth. From the research, scientists aim to explore block the activity of the HDL receptor in breast cancer, and look for ways to limit the harmful effects of HDL in the human body.
The research was led by Philippe Frank, Ph.D., a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University. The research has been published in the journal Breast Cancer Research. The paper is titled "Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development."
More about Cholesterol, Breast Cancer, Cancer, Heart disease
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