Tim Jennings opened the scoring, returning an interception for 48 yards and a score to give Chicago an early 7-0 lead, but the big turnover came late in the fourth quarter, sealing the victory and improving the Bears to 4-2 for the 2013 NFL season.
Jay Cutler had an outstanding game as the veteran completed 24 of 36 passes for 262 yards and two touchdowns, both to wide receiver Brandon Marshall.
Cutler also added 20 yards on three carries and wasn't sacked in the game.
Marshall finished with nine receptions for 87 yards to go with his two scores and running back Matt
Forte added 67 yards on 19 carries.
The NY Giants are now 0-6 and despite the shortcomings of Manning, seemed to have found a running game for the first time this season as Brandon Jacobs rushed for over 100 yards and added two touchdowns in the loss.
Chicago now leads the tough NFC North and will look to keep their success going with a road contest next weekend against the Washington Redskins.