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Fecal transplant treats colitis

By Tim Sandle     Oct 4, 2013 in Science
Fecal transplant has been shown to be successful in assisting patients suffering with chronic intestinal inflammation (ulcerative colitis).
Scientists have shown that fecal transplant, transferring the stool of a healthy person into the gut of someone with an antibiotic resistant microbe infection, has a high success rate for different treatments. As the Digital Journal has reported, fecal transplants have been successful in curing 15 out of 16 patients suffering from a recurrent diarrheal infection.
Such is the growing use of the treatment, that the U.S. Food and Drug Administration (FDA) has issued a guidance note about fecal transplants. A fecal transplant involves transferring the stool of a healthy person into the gut of someone with an antibiotic resistant microbe infection.
New research has examined the use of fecal transplants to alleviate the conditions of Crohn's disease and ulcerative colitis (chronic inflammatory bowel diseases). The initial findings, based on DNA analysis, have shown that the transfer of microorganisms from the feces of people who do not have bowl diseases to those that do, has led to a reduction in the symptoms.
Despite the success, further study is required. This is because the intestinal ecosystem of each individual patient reacted very differently to the fecal transplantation. Whilst intestinal bacteria of the donors were detected in the patients, this was at different times and in different frequencies. This suggests some variability with the process.
The research was led by Sieglinde Angelberger and Walter Reinisch (Medical University Vienna) and microbiologists David Berry and Alexander Loy (University of Vienna). The findings have been published in the journal American Journal of Gastroenterology. The paper is titled “Temporal Bacterial Community Dynamics Vary Among Ulcerative Colitis Patients After Fecal Microbiota Transplantation.”
More about Fecal, fecal transplant, colitis, Inflammatory Bowel Disease
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