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In the Media

article imageCan the Down syndrome chromosome be switched off?

By Tim Sandle
Aug 2, 2013 in Health
2 more articles on this subject:
Researchers have managed to switch off the extra chromosome that causes Down syndrome in cells taken from patients with the condition.
Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21 (that occurs when people inherit three copies of chromosome 21 instead of the usual two). A chromosome is a single piece of coiled DNA containing many genes; the chromosome encodes most of a person’s genetic information.
The condition is typically associated with physical growth delays, a particular set of facial characteristics and a severe degree of intellectual disability. The condition affects one in every 700 babies born in the United States.
For this new study, researchers attempted shut down the extra chromosome by drawing on a biological process called X inactivation (or "genome editing", a procedure that allows DNA to be cut and pasted), according to The Guardian. Women have two X chromosomes and men have only one X and a Y. To halve the amount of X chromosome products, female cells shut down one copy. Cells do that using a chunk of RNA called XIST, which is made by one X chromosome but not the other. The RNA works by pulling in proteins that essentially board up the chromosome like an abandoned building. The other X stays on by making a different RNA.
To demonstrate this, the scientists put the gene for XIST onto one of the three copies of chromosome 21 carried by stem cells grown from a man with Down syndrome. That copy of the chromosome was successfully switched off.
The study advances thinking about the molecular basis of the genetic disorder. The researchers next plan to carry out animal experiments. The long-term aim is for a human trial using gene therapy.
The study was led by Jeanne Lawrence, a chromosome biologist and genetic counselor at the University of Massachusetts Medical School in Worcester. The research findings have been published in Nature in a paper titled “Translating dosage compensation to trisomy 21.”
article:355750:8::0
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