Remember meForgot password?
    Log in with Twitter

article imageNew technique to create transparent brains

By Tim Sandle     Jun 27, 2013 in Science
Researchers have developed a solution that turns tissues transparent. It is hoped that the technique will be used to view neuronal circuits in the human brain, as part of the examination of conditions like Alzheimer's disease.
Scientists in Japan have developed a new sugar and water-based solution that turns tissues transparent in just three days. It is hope that the technique will be used to view neuronal circuits in the human brain.
For the technique, as specially designed aqueous fructose solution (called SeeDB) was used. Once the tissues were rendered transparent, fluorescent dyes were used to visualise the structures. Trials were conducted using the brains of mice, combined with fluorescence microscopy. The method allowed the research team to look deep down into biological structures like the brain.
The implications of such research could help scientists understand the brain. Neuroscientists have yet to unlock the secrets of how people learn and form thoughts. Some researchers think having a “connectome,” or brain wiring diagram showing how the billions of neurons there interface, will help solve the mystery. Such an understanding will help to assess to diseases of the brain and nervous system. These neurological disorders include multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, epilepsy, and stroke. Many can affect a person's memory and ability to perform daily activities.
The new technique has been described in the journal Nature Neuroscience. The paper is titled “SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction.”
More about Brains, Mice, Humans, Tissue, Health
More news from
Latest News
Top News