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article imageResearch: Coffee fights breast cancer, improves tamoxifen effect Special

By E. Hector Corsi     May 22, 2013 in Health
New research shows that moderate to high coffee consumption can prevent some types of breast cancer and improve response to tamoxifen.
A new study shows that subjects who consume five or more cups of coffee per day have a significant reduced risk of breast cancer, compared to those who don't drink any coffee.
Furthermore, drinking lots of coffee was linked to a reduced risk of estrogen receptor negative (ER-) breast cancer and postmenopausal breast cancer. It’s important to note that it’s high coffee consumption that was linked to reduced risks, and not caffeine. There was no effect by a gene involved in caffeine metabolism, CYP1A2. The research was conducted by Elizabeth C. Lowcock and her colleagues at Prevention and Cancer Control, Cancer Care Ontario, in Toronto and at the University of Toronto. Researchers examined 3062 patients with breast cancer and compared them to a group of 3427 subjects who were the controls.
I asked Elizabeth Lowcock, Senior Research Associate at Cancer Care Ontario, if she examined the use of decaffeinated coffee. She said that decaffeinated coffee had "no association with breast cancer risk," but that only the use of 3 or more cups of this coffee was examined, versus 5 or more cups for regular coffee. The study was published in the journal Nutrition and Cancer.
However, another new but smaller study showed that patients who drank a high amount of coffee (5+ cups/day) had a greater risk of ER- breast cancer. Researchers tested if coffee had effects on the characteristics of breast tumors and on the risk of early events when tamoxifen was also administered, and genes involved in caffeine and tamoxifen metabolism were examined (CYP1A2 and CYP2C8). Please note that patients can have their breast tumor tested for estrogen receptor status. The good news is that patients with ER positive breast cancer (ER+) who drank moderate amounts to lots of coffee (2 to 5 cups or more), and received tamoxifen treatment had a significantly lower risk of early events, compared to those who drank zero to one cups/day. Tamoxifen-treated patients with at least one CYP1A2*1F C-allele or CYP2C8*3 who drank low amounts of coffee had a higher risk of early events. Thus, if you have ER+ breast cancer, and will receive tamoxifen, speak with your doctor about the beneficial role of more coffee.
A recent meta-analysis that included 49497 breast cancer cases also examined the effect of coffee. Researchers found that high coffee consumption lowered the risk of ER- breast cancer.
Thus, drinking moderate amounts to lots of coffee could prevent breast cancer.
More about coffee breast cancer, coffee estrogen receptor negative breast cancer, Coffee, coffee tamoxifen
 
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