The Puerto Rican slugger has dominated the fight from first to the eighth round with a series of combinations that caused Margarito's right eye to swell, prompting doctors at ringside to stop the fight in order to prevent more damages to eye of the Mexican.
It may be recalled that Margarito suffered a broken orbital bone
on his right eye in the hands of pound-for-pound king Manny Pacquiao early this year.
In the early rounds Cotto started targeting Margarito's surgically-repaired right eye until it began to swell in the later rounds, prompting the ring physicians to stop the fight before the start of the 10th round.
In 2008 Cotto suffered his first loss in his professional career in the hands of Margarito via 11th round TKO in a bloody fight held at the MGM Grand in Las Vegas, Nevada.
The following year, Margarito was caught with illegal substance
in his hand wraps a few minutes before he entered the ring during his fight with Shane Mosley at the Staples Center, California, in 2009.
After the illegal hand wraps incident in 2009, Margarito's license to fight in California was suspended along with his trainer Javier Capetillo after a thorough investigation by the state regulating agency.
Because of his suspension that was triggered by the illegal hand wraps, boxing insiders and critics speculated the same may have been used by Margarito in their first encounter.
It was reported after the stoppage that Margarito's handlers beg the ring authorities to continue with the fight but the doctor's verdict was final.
With the win Cotto retained his WBA super welterweight crown and banked $5 million
plus share in pay-per-view buys while Margarito made $2.5 million plus smaller share of the PPV sales.