Edge - real name Adam Copeland - announced his retirement due to injurys sustained over several matches.
He has been suffering from neuropraxia, characterised by symptoms such as numbness and uncontrollable trembling.
The WWE's official statement
claims that this is not the first time that Edge has suffered from the muscular disorder.
"An MRI administered at Atlanta Midtown Diagnostic Imaging last Monday was sent to Dr. Joseph Maroon, a renowned neurosurgeon and professor of neurosurgery at The Pittsburgh School of Medicine. After careful examination of the MRI, it was determined that Edge would never be cleared to compete again, and thus, he is forced to retire."
Copeland, 37, made his debut under the Edge moniker on June 22, 1998.
In his thirteen year career, the Canadian-born wrestler won the World Heavyweight Championship a grand total of seven times, as well as becoming a four-time WWE Champion.
Amongst his many accolades include successful tag team championship reigns with wrestlers Christian, Chris Benoit, Hulk Hogan, Rey Mysterio, Randy Orton and Chris Jericho.
He is also a five-time Intercontinental Champion, a WCW United States champion, a two-time Money In The Bank winner and the winner of the 2001 King of the Ring tournament.
With his retirement came the vacation of the WWE's World Heavyweight Championship.