Researchers have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum München.
A cooperative effort by colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universität München and scientists at the Helmholtz Zentrum München has pinpointed a major gene for allergic diseases.
The newly
discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. Dr. Stephan Weidinger from the Technische Universität München and Dr. Thomas Illig from the Helmholtz Zentrum München led the team of scientists which found that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies.
IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle countries with less contact, however, elevated IgE levels are associated with allergic disorders.
The immune system, in individuals who are genetically susceptible, becomes biased and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with certain cells to get rid of the allergens, a process that gives rise to the symptoms of allergy such as allergic rhinitis (hay fever), atopic dermatitis or asthma.
“Most people with allergies are atopic, meaning they have a genetic tendency to develop allergies. To detect the genetic factors we examined the genomes of more than 10,000 adults and children from the whole of Germany" explained Stephan Weidinger.
The people who were examined for the study, for the most part, came from the population studies of the KORA (co-operative health research in the Augsburg region) research platform, which is led by Prof. Dr. H.-Erich Wichmann, the Director of the Institute of Epidemiology at the Helmholtz Zentrum München.
The allergological examinations were carried by the Department for Dermatology and Allergy of the Technische Universität München headed by Prof. Dr. Dr. Johannes Ring.
The new knowledge on the regulation of IgE production does have the potential to guide the development of new drugs.
Munich Researchers Discover Key Allergy Gene
Email
Print
Share
del.icio.us
facebook
newsvine
reddit
stumbleupon
technorati