Blue Gene/P is three times more potent than the current fastest machine, BlueGene/L.
The latest number cruncher is capable of operating at so called "petaflop" speeds - the equivalent of 1,000 trillion calculations per second.
Approximately 100,000 times more powerful than a PC, the first machine has been bought by the US government.
It will be installed at the Department of Energy's (DOE) Argonne National Laboratory in Illinois later this year.
Two further machines are planned for US laboratories and a fourth has been bought by the UK Science and Technology Facilities Council for its Daresbury Laboratory Cheshire.
The ultra powerful machines will be used for complex simulations to study everything from particle physics to nanotechnology
Currently the most powerful machine is Blue Gene/L, housed at the Lawrence Livermore National Laboratory in California.
Used to ensure that the US nuclear weapons stockpile remains safe and reliable, it has achieved 280.6 teraflops or trillions of calculations per second.
The machine packs 131,072 processors and is theoretically capable of reaching 367 teraflops.
By comparison the standard one petaflop Blue Gene/P comes with 294,912-processors connected by a high-speed, optical network.
Blue Gene/L plans to retire from competitive computing completely, with no plans to go into coaching or TV.